Cerebrospinal fluid neurogranin as a new player in prion disease diagnosis and prognosis

作     者：Anna Villar-Piqué Inga Zerr Franc Llorens Anna Villar-Piqué;Inga Zerr;Franc Llorens

作者机构：Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Institute Carlos IIIMinistry of HealthHospitalet de LlobregatSpain Bellvitge Biomedical Research Institute (IDIBELL)Hospitalet de LlobregatSpain Department of NeurologyClinical Dementia Center and National Reference Center for CJD SurveillanceUniversity Medical SchoolGotingenGermany German Center for Neurodegenerative Diseases (DZNE)GotingenGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第5期

页      面：861-862页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：funded by the Spanish Ministry of Health-Instituto Carlos Ⅲ(Miguel Servet programme-CP/00041) to FL 

主　　题：Represa cerebrospinal fluid multiple system 

摘      要：Neurogranin (Ng) and its role as Alzheimer’s disease (AD) biomarker: Ng is a calmodulin-binding protein mainly expressed in cerebral structures such as the cortex,hippocampus and striatum.It is mainly located in the dendritic processes,particularly in post-synaptic compartments,but also in the cytosolic compartment,being likely involved in the regulation of the intracellular calcium-calmodulin signaling pathway (Represa et al.,1990).In the last decade,a plethora of studies have demonstrated that cerebrospinal fluid (CSF) Ng is increased in AD patients and in individuals with an ADlike CSF profile (Kester et al.,2015a).This increase seems to be disease-specific because other neurodegenerative conditions including frontotemporal dementia,Lewy body dementia,Parkinson’s disease,progressive supranuclear palsy,multiple system atrophy or Huntington’s disease,present CSF Ng concentrations similar to controls (Wellington et al.,2016).Ng levels in CSF appear to be elevated in mild cognitive impairment (MCI)-affected individuals who progress to AD and are highly related to memory and cognitive function (Kester et al.,2015a;Tarawneh et al.,2016),which indicates that this protein may serve as an early AD biomarker with diagnostic utility in pre-dementia disease stages,and with prognostic utility to predict cognitive decline and MCI-to-AD conversion.