Chapter 6 Non-inferiority Trial

作     者：Peter Pang Peter Pang

作者机构：Yan Chai Hospital 

出 版 物：《实用休克杂志（中英文）》 (Journal of Practical Shock)

年 卷 期：2019年第3卷第4期

页      面：254-256页

学科分类：08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：agent incremental illustrate 

摘      要：What is Non-inferiority trial(NI)?NI is designed to see whether a new test agent is Not Unacceptably less efficacious than a standard treatment with well-established historical *** continuous updates in primary studies and clinical uses,incremental benefits of newly developed treatments may be marginal over current *** design another 3-arms RCT of new test agent to a standard treatment,as well as,placebo group may be unethical and a waste of *** such circumstances,there has been increasing use of *** are more complex to design,conduct,and interpret than traditional superiority *** illustrate with a 3-arms diagram below.