Central regulation of breast cancer growth and metastasis

作     者：Jeremy C.Borniger 

作者机构：Department of Psychiatry&Behavioral SciencesStanford University School of MedicineP154 MSLS Building1201 Welch Rd.StanfordCA 94305USA 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2019年第4卷第3期

页      面：90-107页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by NIMH BRAIN Initiative (F32 MH115431) 

主　　题：Breast cancer hypothalamus immunometabolism sympathetic nervous system neuromodulators 

摘      要：Cancer is a systemic disease. In order to fully understand it, we must take a holistic view on how cancer interacts with its host. The brain monitors and responds to natural and aberrant signals arriving from the periphery, particularly those of metabolic or immune origin. As has been well described, a hallmark of cancer is marked disruption of metabolic and inflammatory processes. Depending on the salience and timing of these inputs, the brain responds via neural and humoral routes to alter whole-body physiology. These responses have consequences for tumor growth and metastasis, directly influencing patient quality of life and subsequent mortality. Additionally, environmental inputs such as light, diet, and stress, can promote inappropriate neural activity that benefits cancer. Here, I discuss evidence for brain-tumor interactions, with special emphasis on subcortical neuromodulator neural populations, and potential ways of harnessing this cross-talk as a novel approach for cancer treatment.