SecA inhibitors:next generation antimicrobials

作     者：Arpana Chaudhary Yinghsin Hsieh Hsiuchin Yang Phang C.Tai 王炳和 

作者机构：Departments of BiologyCenter for Diagnostics and Therapeuticsand Center for Biotechnology and Drug DesignGeorgia State University Departments of Chemistry Center for Diagnostics and Therapeuticsand Center for Biotechnology and Drug DesignGeorgia State University 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2012年第21卷第6期

页      面：526-530页

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

主　　题：SecA inhibitors Antimicrobials Natural sources Small-molecule inhibitors 

摘      要：Health problems caused by bacterial infection have become a major public health concern in recent years due to the widespread emergence of drug-resistant bacterial ***,the need for the development of new types of antimicrobial agents,especially those with a novel mechanism of action,is ***,one of the key components of the secretion(Sec) pathway,is a new promising target for antimicrobial agent *** recent years,promising leads targeting SecA have been identified and the feasibility of developing antimicrobial agents through the inhibition of SecA has been *** hope this review will help stimulate more research in this area so that new antimicrobials can be obtained by targeting SecA.