Mineral and bone disorder and management in the China Dialysis Outcomes and Practice Patterns Study

作     者：Jun Wang Brian A.Bieber Fan-Fan Hou Friedrich K.Port Shuchi Anand Wang Jun;Bieber Brian A.;Hou Fan-Fan;Port Friedrich K.;Anand Shuchi

作者机构：National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchDivision of NephrologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Arbor Research Collaborative for HealthAnn AborMlUSA Division of NephrologyStanford University School of MedicinePalo AltoCAUSA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2019年第132卷第23期

页      面：2775-2782页

核心收录：

学科分类：08[工学] 082503[工学-航空宇航制造工程] 0825[工学-航空宇航科学与技术] 

基　　金：This work was supported by grants from the Global support for the ongoing DOPPS Programs without restriction on publications by a variety of funders(For details see https://www.dopps.org/AboutUs/Support.aspx) Dr.Shuchi Anand is supported by U.S.National Institute of Diabetes,and Digestive and Kidney Diseases(No.NIDDK K-235K23DK101826-03) Dr.Jun Wang is supported by the National Natural Science Foundation of China(No.81470972) 

主　　题：Mineral bone disease Hyperphosphatemia Hyperparathyroidism China Hemodialysis Dialysis Outcomes and Practice Patterns Study 

摘      要：Background:Despite a growing population of patients starting hemodialysis in China,little is known about markers of mineral bone disease(MBD)and their *** present data on prevalence and correlates of hypocalcemia,hyperphosphatemia,and secondary hyperparathyroidism from the China Dialysis Outcomes and Practice Patterns Study(DOPPS),with evaluation of whether these laboratory markers triggered changes in ***:We compared the frequency of measurement and prevalence of poor control of MBD markers in China DOPPS with other DOPPS *** also used generalized estimating equations to assess correlates of MBD markers,and separate models to assess predictors of vitamin D and phosphate binder prescriptions in the China ***:Severe hyperphosphatemia(7 mg/dL)and secondary hyperparathyroidism(600 pg/mL)were common(27%and 21%prevalence,respectively);both were measured infrequently(14.9%and 3.2%of patients received monthly measurements in China).Frequency of dialysis sessions was positively associated with hyperphosphatemia;presence of residual kidney function was negatively associated with both hyperphosphatemia and secondary *** measures indicating poor control of MBD were not associated with subsequent prescription of active vitamin D or phosphate ***:There are substantial opportunities for improvement and standardization of MBD management in *** of country-specific guidelines may yield realistic targets and standardization of medication use accounting for availability and cost.