Effect of moxibustion on survival status and nutritional metabolic factor in tumor-bearing rats with gastric cancer

作     者：彭卓隽 谭静 陈欲攀 赵欢 石峻林 林亚平 Zhuojun PENG;Jing TAN;Yupan CHEN;Huan ZHAO;Junlin SHI;Yaping LIN

作者机构：湖南中医药大学针灸推拿学院长沙410208 湖南中医药大学中医学国内一流建设学科长沙410208 

出 版 物：《World Journal of Acupuncture-Moxibustion》 (世界针灸杂志（英文版）)

年 卷 期：2019年第29卷第3期

页      面：210-215页

核心收录：

学科分类：1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by National Natural Science Foundation Project:1574077 Excellent Youth Project of Hunan Education Department:188257 

主　　题：Moxibustion Tumor-bearing rats with gastric cancer Survival status Blood glucose(GLU) Albumin(ALB) Total protein(TP) Triglyceride(TG) Viscera-free weight 

摘      要：Objective:To observe the effect of moxibustion on the survival status and nutritional metabolic factors of tumor-bearing rats with gastric cancer and explore the inhibitory effect of moxibustion on the tumorbearing rats.Methods:A total of 40 SD rats were randomly divided into a blank group,a sham-operated group,a model group and a moxibustion group,10 rats in each group.Gastric cancer models were established in the model group and the moxibustion group.The rats of all the groups underwent the same constraining procedure for 20 min every day.Additionally,moxibustion was applied at acupoints for 20 min in the rats of the moxibustion group.There were two groups of acupoints.One group includedZusanli(足三里ST 36)Zhongwan(中脘CV12)andGuanyuan(关元CV4).The other group included bilateralPishu(脾俞BL 20)andWeishu(胃俞BL 21).Moxibustion was applied for 20 min every day at the acupoints of the two groups alternatively and lasted for 14 days.The survival status of rats was observed and the score of survival status and body weight of rats were recorded every day.At the end of intervention,the orbital blood was collected and the rats were sacrificed for sample collection.The viscera-free body weight was recorded.Using biochemical analyzer,the blood glucose(GLU),albumin(ALB),total protein(TP)and triglyceride(TG)in serum were detected.Results:(1)Regarding the score of the survival status,after modeling,the scores in the model group and the moxibustion group were all higher than those of the sham-operation group(both P0.05).After intervention,the score in the moxibustion group was lower than that of the model group(P0.05).(2)After modeling,the body weight in the moxibustion group and the model group was lower than those of the blank group,indicating a statistical significance(both P0.05).The body weight in the moxibustion group was higher than that of the model group after intervention,indicating the statistical significance(P0.05).(3)Regarding the viscera-free body weight,it was lower in the model group compared with the sham-operation group,indicating the statistical significance(P0.05).Compared with the model group,the viscera-free body weight was higher in the moxibustion group,indicating the statistical significance(P0.04).(4)Regarding the nutritional metabolic factors,compared with the sham-operation group,the levels of GLU and ALB in the model group were lower and TP was higher,presenting the statistical significance(all P0.05).Compared with the model group,the levels of GLU and ALB were higher in the moxibustion group and TP was lower,presenting the statistical significance(all P0.05).Conclusion:Moxibustion improves the survival status of tumor-bearing rats with gastric cancer,increases the body weight,the viscera-free body weight and the levels of GLU and ALB in serum and reduces TP of the tumor-bearing rats with gastric cancer and inhibits the growth of gastric cancer.