Research on viral dynamic models of hepatitis B virus infection

作     者：LequanMin XisongDong 

作者机构：AppliedScienceSchoolUniversityofScienceandTechnologyBeijingBeijing100083China／／InformationEngineeringSchoolUniversityofScienceandTechnologyBeijingBeijing100083China InformationEngineeringSchoolUniversityofScienceandTechnologyBeijingBeijing100083China 

出 版 物：《Journal of University of Science and Technology Beijing》 (北京科技大学学报（英文版）)

年 卷 期：2004年第11卷第6期

页      面：572-576页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：ThisprojectisjointlysupportedbytheNationalNaturalScienceFoundationofChina(No.70271068 60074034)andtheResearchFundfortheDoctoralProgramofHigherEducation(No.20020008004)bytheEducationMinistryofChina 

主　　题：mathematical model liver hepatitis B virus lamivudine treatment equilibrium point stability treatment time numeric simulation 

摘      要：A mathematical model with cytotoxic cells of hepatitis B virus (HBV)infection is set up based on a basic model of virus dynamics without cytotoxic cells andexperimental observation of anti-viral drag therapy for HBV infection patients. A quantitativeanalysis of dynamic behaviors shows that the model has three kinds of equilibrium points, whichrepresent the patient s complete recovery without immune ability, complete recovery with immuneability, and HBV persistent infection at the end of the treatment with drag lamivudine,respectively. Our model may provide possible quantitative interpretations for the treatments ofchronic HBV infections with the drag lamivudine, in particularly explain why the plasma virus ofNowak et al. s patients turnover the original level after stopping the lamivudine treatment.