Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria
作者机构：Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical College100050 BeijingChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2019年第4卷第1期
页 面：238-239页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 0701[理学-数学] 070101[理学-基础数学]
主 题：hence outer endogenous
摘 要：In a recent study published in Cell Research,*** Song’s group reported the potent antibacterial activity of three coagulation factors(VII,IX,and X)against gram-negative bacteria and hence discovered a novel class of endogenous host antimicrobial proteins.1 At present,antimicrobial resistance(AMR)poses significant challenges for clinical care and seriously threatens human health.2,3 Among the clinical pathogens,gram-negative bacteria are particularly problematic in terms of drug resistance because their lipopolysaccharide(LPS)-rich outer membrane reduces cellular permeability and acts as a target for antibacterial resistance development.
维普期刊数据库