聚焦超声手术治疗子宫肌瘤的临床效果

作     者：Stewart E.A. Rabinovici J. Tempany C.M.C. 李跃萍 

作者机构：Center for Uterine Fibroids Brigham and Women's Hospital 75 Francis Street Boston MA 02115 United States Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第4期

页      面：23-24页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：聚焦超声 子宫平滑肌瘤 绝经前女性 严重程度评分 子宫体积 学院医学 多中心临床试验 评定量表 生活 

摘      要：Objective: To assess outcomes at 6 and 12 months after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for symptomatic uterine leiomyomas. Design: Multicenter clinical trial. Setting: Academic medical centers. Patient(s): Premenopausal women with symptomatic uterine leiomyomas and no plans for future pregnancy (n = 109 at 6 months and n = 82 at 12 months). Intervention(s): A single treatment session of MRgFUS for uterine fibroids. Main Outcome Measure(s): Reduction in fibroid symptoms as measured by the symptom severity score (SSS) of the Uterine Fibroid Quality-of-Life Instrument (UFS-QOL), the only validated measure of leiomyoma symptomatology. A 10-point reduction in the SSS was selected as the targeted improvement. Result(s): Seventy-one percent of women undergoing MRgFUS reached the targeted symptom reduction at 6 months, and 51%reached this at 12 months. The magnitude of improvement in SSS was greater than predicted, with subjects having a mean decrease of 39%and 36%at 6 and 12 months, respectively. This paralleled the improvement seen using the short form-36 instrument. A modest volume reduction similar in magnitude to the treated volume was seen. The incidence of adverse events was low. Conclusion(s): MRgFUS treatment results in short-term symptom reduction for women with symptomatic uterine leiomyomas with an excellent safety profile.