恶性雀斑样痣的相邻皮损

作     者：Dalton S.R. GardnerT.L. LibowL.F. Elston D.M. 焦婷 

作者机构：Dept. of Pathology and Dermatology Geisinger Medical Center 100 North Academy Ave Danville PA 17822-1406 United States Dr. 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第9期

页      面：60-60页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：恶性雀斑样痣 色素性 光化性角化病 病理医生 活检标本 临床医生 活检术 活组织检查 脂溢性角化病 光性 

摘      要：Background: Determining the best biopsy technique for a suspected lentigo maligna can be challenging. Because complete excisional biopsy is rarely practical, the physician is left to choose an appropriate area to biopsy. Sampling error can have devastating consequences,especially if the biopsy demonstrates a pigmented lesion that was considered in the clinical differential diagnosis. The presence of a solar lentigo, pigmented actinic keratosis, or reticulated seborrheic keratosis could mislead the pathologist and clinician to the erroneous conclusion that the incisional specimen is representative of the whole, and that no lentigo maligna is present. Objective: We have often observed the presence of a contiguous pigmented lesion adjacent to lentigo maligna. The current study was designed to determine how frequently this phenomenon occurs. Methods: We studied Mohs debulking specimens of lentigo maligna, and broad shave biopsy specimens of pigmented lesions on heavily sun-damaged areas of the skin proven to be lentigo maligna. Results: Contiguous pigmented lesions were present in 48%of the specimens. The most common lesion was a benign solar lentigo (30%), followed by pigmented actinic keratosis (24%). Conclusion: Recognition of this phenomenon may prevent misdiagnosis of lentigo maligna related to sampling error.