Gem-Diphosphonates： The Motif of Diverse Biological and Medicinal Importance

作     者：Wafaa Abdou Reham Barghash 

作者机构：Division of Chemical Industries Research National Research Center Dokki Cairo 12311 Egypt 

出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)

年 卷 期：2015年第3卷第4期

页      面：153-169页

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：Bisphosphonates cell adhesion palliative care adjuvant drug therapy osteonecrosis anti-tumor agents. 

摘      要：The introduction of gem-diphosphonates （known as bisphosphonates, BPs） in oncology has dramatically changed the management of patients with metastatic bone disease. In this manuscript, we thoroughly scrutinize the available body of clinical trials supporting the use of bisphosphonates in this setting and review new and ongoing research. Additionally, we summarize the data showing the benefits of BP-use in the prevention of treatment-induced bone loss and the intriguing emerging evidence on the antitumor potential of some of these agents when used in the adjuvant setting. Finally, we address the need for a careful consideration of potential benefits of BPs therapy and the risk for osteonecrosis, a recently recognized late-toxicity of their use.