Association between Tourette Syndrome and the Dopamine D3 Receptor Gene Rs6280

作     者：Fan He Yi Zheng Huan-Huan Huang Yu-Hang Cheng Chuan-Yue Wang 

作者机构：Department of Psychiatry Beijing Anding Hospital Capital Medical University Beijing 100088 China Center of Schizophrenia Beijing Institute for Brain Disorders Beijing 100088 China Department of Psychiatry Beijing Anding Hospital Capital Medical University Beijing 100088 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第5期

页      面：654-658页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071006[理学-神经生物学] 

基　　金：This study was financially supported by the Natural Science Foundation of Beijing No.7132083 the Capital Clinical Application Characteristic Study of Beijing Science and Technology Commission No.D101100050010061 

主　　题：Dopamine D3 Receptor Gene Single Nucleotide Polymorphism Tourette Syndrome Transmission Disequilibrium Test 

摘      要：Background：Tourette syndrome （TS） is a complex,heterozygous genetic *** number of molecular genetic studies have investigated several candidate genes,particularly those implicated in the dopamine *** dopamine D3 receptor （DRD3） gene has been considered as a candidate gene in *** was not any report about the association study of TS and DRD3 gene in Han Chinese *** combined a case-control genetic association analysis and nuclear pedigrees transmission disequilibrium test （TDT） analysis to investigate the association between DRD3 gene rs6280 single nucleotide polymorphisms （SNPs） and TS in a Han Chinese ***：A total of 160 TS patients was diagnosed by the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,Fourth *** DRD3 gene rs6280 SNPs were genotyped by TaqMan SNP genotyping assay technique in all *** used a case-control genetic association analysis to compare the difference in genotype and allele frequencies between 160 TS patients and 90 healthy *** the same time,we used TDT analysis to identify the DRD3 gene rs6280 transmission disequilibrium among 10l nuclear ***：The genotype and allele frequency of DRD3 gene rs6280 SNPs had no statistical difference between control group （90） and TS group （160） （χ^2 =3.647,P =0.161; χ^2 =0.643,P =0.423） using Chi-squared *** the basis of the 101 nuclear pedigrees,TDT analysis showed no transmission disequilibrium ofDRD3 gene rs6280 SNPs （χ^2 =0; P =1）.Conclusions：Our findings provide no evidence for an association between DRD3 gene rs6280 and TS in the Han Chinese population.