Neutropenic enterocolitis:A clinico-pathological review

作     者：Rong Xia Xuchen Zhang 

作者机构：Department of PathologyState University of New YorkDownstate Medical CenterBrooklynNY 11203United States Department of PathologyYale University School of MedicineNew HavenCT 06520United States 

出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)

年 卷 期：2019年第10卷第3期

页      面：36-41页

学科分类：10[医学] 

主　　题：Neutropenic enterocolitis Typhlitis Chemotherapy Neutropenia 

摘      要：Neutropenic enterocolitis(NE)is a predominantly cecum-based disease with high mortality seen in patients post chemotherapy.The pathogenesis of NE is poorly understood and probably multifactorial involving mucosal injury,neutropenia,and impaired host defense to intestinal organisms.The clinical presentation is characterized as ileocolonic inflammation and bowel wall thickening in patients with neutropenia,fever,and abdominal pain.The pathological features of NE include patchy necrosis,hemorrhage,ulcer,edema,perforation,infiltrating organisms,and characteristically,depletion of inflammatory cells(neutrophils).NE should always be considered as a possible diagnosis in immunosuppressed patients,especially those receiving chemotherapy.High clinical and histological diagnostic discordance rate exists.High index of clinical suspicion and prompt appropriate personalized management are essential to achieve a lower mortality rate.