Stereoselective Total Synthesis of Mycalamides

作     者：Masahiro Toyota 

作者机构：Department of Chemistry Graduate School of Science Osaka Prefecture University Sakai Osaka 599-8531 Japan 

出 版 物：《复旦学报（自然科学版）》 (Journal of Fudan University：Natural Science)

年 卷 期：2005年第44卷第5期

页      面：813-814页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：立体选择性 微生物 抗滤过性病原体 抗癌抗菌素 免役抑制 

摘      要：Mycalamides A (1a) and B (1b) are potent antiviral compounds from a New Zealand sponge of the genus Mycale. Apart from their antitumor property, mycalamide A (1a) exhibits immunosuppressive action by blocking T-cell activation in mice and is significantly more potent than FK-506 and cyclosporine A. Because of their intriguing biological activity, unique structures and scarce supply of these natural products, mycalamides A (1a) and B (1b) have attracted considerable attention as target molecules for total synthesis, and total, formal, or partial syntheses of this family of compounds have been reported[1,2].