Synthesis and Anticancer Activity of 2,3,4-Trimethoxyacetophenoxime Ester Containing Benzothiazole Moiety
Synthesis and Anticancer Activity of 2,3,4-Trimethoxyacetophenoxime Ester Containing Benzothiazole Moiety作者机构：Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for Research and Development of Fine Chemicals Guizhou University Guiyang Guizhou 550025 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2005年第23卷第9期
页 面：1236-1240页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：Project supported by the National Key Project for Basic Research (No.2003CB114404) High-tech Research and Development Program of China (No. 2002AA217131) the National Natural Science Foundation of China (Nos. 20442003 and 20362004) and Program for New Century Excellent Talents in University of China (No. NCET-04-0912)
主 题：oxime ester synthesis anticancer activity
摘 要：A series of 2,3,4-trimethoxyacetophenoxime esters containing benzothiazole moiety were synthesized by the reaction of oxime with acyl chloride in alkaline medium. Their structures were established by elemental analysis, IR, and ^1H NMR spectra. The bioassay tests showed that these title compounds exhibit moderate anticancer activity in vitro by MTT method and compounds 6c and 6d could inhibit ERK phosphorylation in NIH 3T3 cell induced by PDGF.
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