Potentiation of apomorphine effect on sildenafil-induced penile erection in conscious rabbits

作     者：Jae-Young Park Hwancheol Son Soo Woong Kim Jae-Seung Paick JAE-YOUNG PARK;HWANCHEOL SON;SOO WOONG KIM;JAE-SEUNG PAICKDEPARTMENT OF UROLOGY;SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE;SEOUL;KOREA DEPARTMENT OF UROLOGY;SEOUL MUNICIPAL BORAMAE HOSPITAL;KOREA

作者机构：Department of UrologySeoul National University College of MedicineSeoulKoreaDepartment of UrologySeoul Municipal Boramae HospitalSeoulKoreaDepartment of UrologySeoul National University College of MedicineSeoulKoreaDepartment of UrologySeoul National University College of MedicineSeoulKorea 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2004年第6卷第3期

页      面：205-209页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：penile erection sildenafil apomorphine conscious rabbit combination therapy 

摘      要：Aim: To investigate a possible potentiation effect of apomorphine (APO) on sildenafil-induced penile erection in the conscious rabbit. Methods: Erection of male New Zealand White rabbits (3.5-4.0 kg, n=12) was assessed by measuring the length of the uncovered penile mucosa and the duration of erection before and after intravenous administration of agents. After injection of APO (0, 0.05, 0.1 and 0.4 mg/kg), sildenafil was administered intravenously in a dose-response manner (0.5, 1 and 5 mg/kg). In additional experiments, the effect of increasing doses of sildenafil in combination with APO on systemic blood pressure was evaluated. Results: Systemic administration of sildenafil induced a dose-dependent increase in the penile length. Intravenous injection of APO alone did not produce any change in the penile length, while significantly enhanced the penile erection induced by sildenafil. The co-administration of 0.1 mg/kg of APO and 1 mg/kg of sildenafil was found to be the most effective combination in producing penile erection. Intravenous administration of sildenafil caused a concentration-dependent decrease in systemic blood pressure, but no additional decrease was observed with co-administration of APO. Conclusion: APO enhances the penile erection induced by sildenafil in the conscious rabbit without causing an additional decrease in blood pressure.