Tuberculosis in Takayasu arteritis: a retrospective study in 1105 Chinese patients

作     者：Ying ZHANG Peng FAN Fang LUO Hui-Min ZHANG Lei SONG Wen-Jun MA Hai-Ying WU Jun CAI Lin-Ping WANG Xian-Liang ZHOU 

作者机构：Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2019年第16卷第8期

页      面：648-655页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China (2016YFC1300100) CAMS Innovation Fund for Medical Sciences (2016I2M-1-002) 

主　　题：Immunosuppressive agents Mycobacterium tuberculosis Pulmonary artery Takayasu arteritis 

摘      要：Background Tuberculosis (TB) infection has been reported to have a possible relationship with the occurrence and clinical course of Takayasu arteritis (TA). We aimed to describe the characteristics of TB in a large population of TA patients. Methods We included a total of 1105 patients with TA, who were hospitalized between January 1992 and December 2017. Comparisons of clinical features were made according to the presence of TB. Results Among the 1105 patients, 109 (9.9%) had TB, including 53 patients (48.6%) diagnosed with TB before the onset of TA, 23 (21.1%) with a concurrent diagnosis of TB and TA, and 24 patients (22.0%) who developed TB after TA. Pulmonary TB was the most frequently identified (97 patients, 89.0%). Patients with TB had more frequent involvement of the pulmonary artery and experienced more chest discomfort and constitutional symptoms but had less interventional treatment. Demographic characteristics, comorbid diseases, and use of steroids were similar between patients with and without TB. Conclusions The proportion of Chinese TA patients with TB was not low, and about half of the patients had TB before TA. Pulmonary TB was the most common. Pulmonary artery involvement and pulmonary hypertension was more frequent in TA patients with TB.