Apoptosis during β-mercaptoethanol-induced differentiation of adult adipose-derived stromal cells into neurons

作     者：Yanan Cai Xiaodong Yuan Ya Ou Yanhui Lu 

作者机构：Department of Neurology Kailuan General Hospital Hebei United University Tangshan 063000 Hebei Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第10期

页      面：750-755页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 09[农学] 071009[理学-细胞生物学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

主　　题：adult adipose-derived stromal cells induced differentiation neurons ultrastructure apoptosis 13-mercaptoethanol neural regeneration 

摘      要：β-mercaptoethanol can induce adipose-derived stromal cells to rapidly and efficiently differentiate into neurons in ***,because of the short survival time of the differentiated cells,clinical applications for this technique are *** such,we examined apoptosis of neurons differentiated from adipose-derived stromal cells induced with β-mercaptoethanol in vitro using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and transmission electron *** results revealed that the number of surviving cells decreased and apoptosis rate increased as induction time *** together,these results suggest that apoptosis occurring in the process of adipose-derived stromal cells differentiating into neurons is the main cause of cell ***,the mechanism underlying cellular apoptosis should be researched further to develop methods of controlling apoptosis for clinical applications.