Characteristics of Baicalin Synergy with Penicillin or Notopterygium Ethanol Extracts Against Staphylococcus aureus

作     者：孟甄 郑进燮 游雪甫 邢东明 王伟 杜力军 

作者机构：Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China 

出 版 物：《Tsinghua Science and Technology》 (清华大学学报（自然科学版（英文版）)

年 卷 期：2006年第11卷第4期

页      面：459-461页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Basic Research Foundation of Tsinghua University 

主　　题：baicalin synergy minimum inhibitory concentration Staphylococcus aureus 

摘      要：Baicalin facilitates the effectiveness of both penicillin and Notopterygium ethanol extracts （NEE） on Staphylococcus aureus. Two Staphylococcus aureus strains, ATCC29213 and 03-21 （a clinical isolate）, were tested. When combined with 128 μ***^-1 of baicalin, the minimum inhibitory concentration （MIC） of penicillin was reduced from 0.25 μ***^-1 to 0.06 μ***^-1, while that of NEE was reduced from 32 μg·mL^-1 to 8μg·mL^-1 against ATCC29213. Against the 03-21 strain, the MIC of penicillin was reduced from 4 μ***^-1 to 1 μ***^-1, while that of NEE was reduced from 32 μ***^-1 to 4 μg·mL^-1. Viable number counting results show that combination of baicalin and penicillin acts on the killing mechanism, while the baicalin and NEE acts on the inhibition. These results show that baicalin acts as a synergistic ally with both penicillin and NEE but has different modes of action.