Anti-Nociceptive Effect in Mice of Thillai Flavonoid Rutin

作     者：Gurudeeban Selvaraj Satyavani Kaliamurthi Ramanathan Thirungnasambandam Lalitha Vivekanandan Balasubramanian Thangavel 

作者机构：Centre of Advanced Study in Marine Biology Faculty of Marine Sciences Annamalai University Nandha College of Pharmacy and Research Institute Erode Tamil Nadu India 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2014年第27卷第4期

页      面：295-299页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Anti-Nociceptive Effect in Mice of Thillai Flavonoid Rutin CF HIS oral RMSD 

摘      要：We investigated the anti-nociceptive effect of Excoecorio ogollocho （***） against chemically and thermally induced nociception, Albino mice received a dose of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction （Alk-CF） of *** by oral administration. Compared with controls, AIk-CF decreased the writhing numbers （P〈0.01） in a dose dependent manner. Further we determined that, AIk-CF contained, a potent compared to control, also potent anti-nociceptive agent that acted via opioid receptors and using HPLC, identified this compound as Rutin. Docking simulation demonstrated that Rutin interacted strongly with cyclooxygenase, forming a number of specific hydrogen bonds. In conclusion we have identified peripheral and central anti-nociceptive activities of *** that involve opioid receptor, and in which the active compound is Rutin.