Polymorphisms of dihydropyrimidine dehydrogenase gene and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population

作     者：ZHANG Xiao-ping BAI Zhi-bin CHEN Bao-an FENG Ji-feng YAN Feng JIANG Zhi ZHONG Yue-jiao WU Jian-zhong CHEN Lu LU Zu-hong TONG Na ZHANG Zheng-dong XU-Pei-pei PENG Miao-xin ZHANG Wen-jing WANG Shuai 

作者机构：Department of Hematology and OncologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsu 210009China Department of General SurgeryZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsu 210009China Department of OncologyMedical SchoolSoutheast UniversityNanjingJiangsu 210009China Jiangsu Province Cancer InstituteNanjingJiangsu 210009China National Key Laboratory for BioelectronicsSchool of BiologicalScience and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China Department of Epidemiology and BiostatisticsNanjing MedicalUniversityNanjingJiangsu 210029China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第5期

页      面：741-746页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 0713[理学-生态学] 10[医学] 

基　　金：国家973计划 the Science and Technology Department of Jiangsu Province the Southeast University Science andTechnology 

主　　题：gastric cancer single nucleotide polymorphisms dihydropyrimidine dehydrogenase fluorouracil 

摘      要：Background Dihydropyrimidine dehydrogenase （DPD）, a key enzyme involved in the catabolism of 5-fluorouracil （5-FU）, is the attractive candidate for pharmacogenetic research on efficacies and toxicities of 5-FU. The aim of this study is to explore the association between polymorphisms of dihydropyrimidine dehydrogenase gene （DPYD） and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in the Chinese population.