帕金森病患者的慢频振动活动和左旋多巴诱导的运动障碍
Slow oscillatory activity and levodopa-ind-uced dyskinesias in Parkinson’s disease作者机构：Department of Neurology and Neurosurgery Clinica Universitaria Avenida de Pio XII 36 Pamplona 31008 Spain
出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)
年 卷 期：2006年第11期
页 面：18-19页
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
摘 要：The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson’s disease is not well understood. We have recorded local field potentials (LFP) from macroelectrodes implanted in the subthalamic nucleus (STN) of 14 patients with Parkinson’s disease following surgical treatment with deep brain stimulation. Patients were studied in the ‘Off’medication state and in the‘On’motor state after administration of levodopa-carbidopa (po) or apomorphine (sc) that elicited dyskinesias in 11 patients. The logarithm of the power spectrum of the LFP in selected frequency bands (4-10, 11-30 and 60-80 Hz) was compared between the ‘Off’and ‘On’medication states. A peak in the 11-30 Hz band was recorded in the’Off’medication state and reduced by 45.2%(P 0.001) in the ‘On’state. The‘On’was also associated with an increment of 77. 6%(P 0.001) in the 4-10 Hz band in all patients who showed dyskinesias and of 17.8%(P 0.001) in the 60-80 Hz band in the majority of patients. When dyskinesias were only present in one limb (n = 2), the 4-10 Hz peak was only recorded in the contralateral STN. These findings suggest that the 4-10 Hz oscillation is associated with the expression of LID in Parkinson’s disease.
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