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2D and 3D Analysis of Magnetocardiographic Data in the Evaluation of the Ventricular Repolarization Changes under Exercise Stress Test in Patients with CAD

2D and 3D Analysis of Magnetocardiographic Data in the Evaluation of the Ventricular Repolarization Changes under Exercise Stress Test in Patients with CAD

作     者:Illya Chaikovsky Leonid Stadnyuk Georg Mjasnikov Anatoly Kazmirchuk Sergy Sofienko Victor Kozlovsky Tatjana Ryzenko Ekaterina Ryschlik Mykola Budnyk Volodymyr Sekretny 

作者机构:Institute of Cybernetics of National Academy of Sciences Kiev Ukraine M.D. Strazesko National Scientific Center of Cardiology Kiev Ukraine Main Military Clinical Hospital Kiev Ukraine Shupyk Natioinal Medical Academy of Post-Graduated Education Kiev Ukraine 

出 版 物:《World Journal of Cardiovascular Diseases》 (心血管病(英文))

年 卷 期:2014年第4卷第8期

页      面:399-404页

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主  题:Magnetocardiography Coronary Artery Disease Magnetic Field Distribution Maps Exercise Stress Test Equivalent Dipole 

摘      要:Objective: Non-invasive methods of evaluation of electrical activity of the heart are still the most important functional diagnostics methods in coronary artery disease (CAD) detection. It has been shown that magnetocardiography (MCG) appears to be rather sensitive in diagnostics of chronic CAD even in the patients at rest with unchanged ECG. The objective of present paper is to investigate the influence of non-invasive tests with a physical exerciseon MCG parameters in the patients with chronic CAD. Materials and Methods: In total, 10 patients were examined (mean age 41 ± 5 years) suffering from chronic stable angina (CAD). CAD was diagnosed by clinical evidences, bicycle ergometria positive data and coronary angiography (stenosis 70% in at least onr main coronary angiography). The control group consisted of 14 healthy volunteers. MCG mapping was performed by means of a 7-channel SQUID-magnetometer installed in an unshielded room. The MCG examination was conducted twice, whilst patients were at rest and after exercise on the bicycle (in healthy persons it was conducted immediately after exercise and in the patients, after the ST depression and/or chest pain had disappeared). The homogeneity and electric motive force (EMF) direction disturbances on magnetic field distribution maps on an extent of ST-T interval have been evaluated. Results: Statistically significant differences between groups examined based both on 2D and 3D quantitative criteria were demonstrated. Conclusion: The application of a set of MCG criteria based on the analysis both of ventricular depolarization and repolarization will enable a greater degree of accuracy for the results of the exercise stress test, especially in doubtful cases.

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