Idiopathic Giant Cell Myocarditis: State of the Art

作     者：Alessia Veia Chiara Cavallino Sara Bacchini Fabio Pastore Alessandro Lupi Andrea Rognoni Francesco Rametta Angelo Sante Bongo 

作者机构：Coronary Care Unit A.O.U. Maggiore della Carità Novara Italy Division of Cardiology A.S.L. Vercelli Italy 

出 版 物：《World Journal of Cardiovascular Diseases》 (心血管病（英文）)

年 卷 期：2014年第4卷第6期

页      面：316-324页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Giant Cell Myocarditis Endomyocardial Biopsy Heart Failure Immunosuppression 

摘      要：Giant cell myocarditis (GCM) is a rare, rapidly progressive and highly lethal disease in young and middle-aged adults. It is attributed to an inflammation of the heart muscle, and mediated by T lymphocytes and anti-myosin autoantibodies. Making diagnosis of GCM with multiple noninvasive imaging modalities is possible in a small percentage of patients, so myocardial tissue diagnosis is often required. An early diagnosis is very important, because immunosuppressive treatment may significantly improve clinical course and survival of these patients. GCM often escapes diagnosis until autopsy or transplantation and has defied proper treatment trials for its rarity and deadly behavior. This review will focus on the diagnostic approach to patients with suspected GCM and currently evidence-based treatment strategy for this disease.