Triptolide-loaded microemulsion-based hydrogels: physical properties and percutaneous permeability

作     者：Lihua Chen Xiaoting Zhao Jia Cai Yongmei Guan Sen Wang Hongning Liu Weifeng Zhu Junsong Li 

作者机构：Key Laboratory of Modern Preparation of TCMMinistry of EducationJiangxi University of TCMNanchang 330004China College of PharmacyNanjing University of Chinese MedicineNanjing 210023China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2013年第3卷第3期

页      面：185-192页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：by the Advanced Technology Platform of TCM Delivery System from State Center for Drug Research and Development(No.2009ZX09310-005) Jiangxi Young Scientist Training Program(No.20112BCB23011) Jiangxi Science and Technology Pillar Program(No.2010BSA18400) 

主　　题：Microemulsion-based hydrogel Rheological properties Environmental scanning electron microscopy Triptolide In vitro permeation 

摘      要：Triptolide is a diterpenoid compound that inhibits the inflammation of rheumatoid arthritis(RA).However,the use of triptolide is limited due to its strong gastrointestinal *** purpose of this work was to develop a transdermal delivery system for triptolide to reduce this toxicity.A microemulsion-based hydrogel(MBH)was prepared from the combination of Gemseal 40-oleic acid as oil phase,Tween 80-labrasol as surfactant,anhydrous ethanol as co-surfactant,water as aqueous phase and Poloxamer 407 as hydrogel *** measurements,environmental scanning electron microscopy(ESEM)and transdermal experiments in vitro were used to characterize triptolide-loaded and blank MBH *** effects of Poloxamer 407 and triptolide on the rheological properties and microstructures of the MBH were *** and homogeneous MBH could only be formed when the concentration of Poloxamer 407 in the selected O/W microemulsion was in the range of 14.0–16.0%(w/w).When the concentration of Poloxamer 407 increased,the rheological properties such as the yield stresses(sy),storage and loss moduli(G′,G″)of the formulations increased,and the network structures became more *** addition of triptolide did not change the interconnected network structures of the MBH *** preparations afford a better sustained release profile when compared to microemulsions,a finding confirmed by an in vitro permeation test in *** appears to be a promising vehicle for transdermal delivery of triptolide.