Myocarditis—Personalized Medicine by Expanded Endomyocardial Biopsy Diagnostics
心内膜心肌活检诊断心肌炎个体化用药作者机构：Institute of Cardiac Diagnostics and TherapyBerlinGermany Department of Cardiology and PneumonologyCharite—University Medicine BerlinCampus Benjamin FranklinBerlinGermany
出 版 物：《World Journal of Cardiovascular Diseases》 (心血管病（英文）)
年 卷 期：2014年第4卷第6期
页 面：325-340页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the German Research Foundation (DFG) Molecular Pathogenesis and Therapy” (SFB TR19, Z1) two grants of the Federal Ministry of Education
主 题：Cardiomyopathy Endomyocardial Biopsy Personalized Medicine Biomarker MicroRNAs
摘 要：Myocarditis and dilated cardiomyopathy (DCM) are acute or chronic disorders of myocardium. The gold standard for final confirmation of causative reasons of these heart muscle diseases is the endomyocardial biopsy (EMB) analysis. Due to focal pathology, diagnostics are failing if the EMB does not contain the area of interest. Personalized medicine comprises the genetic information together with the phenotypic and environmental factors to yield a tailored healthcare for each individual and removes the limitations of the “one-size-fits-all therapy approach. This provides the opportunity to translate therapies from bench to bedside, to diagnose and predict disease, and to improve patient-tailored treatments based on the unique signatures of a patient’s disease. Furthermore, novel treatment schedules can be identified which have eventually the chance to enhance long-term survivals. Global biomarkers such as specific gene expression signatures or miRNA profiles not only have the potential to reduce this problem but also add valuable information for individualized therapy decisions. In future, multiplex approaches allowing rapid and absolutely reliable identification of inflammatory or virally-induced myocardial diseases will replace singleplex methods such as direct detection of viral genomes in one single biopsy. Gene or miRNA profiles are upcoming diagnostic biomarkers for cardiomyopathies which are not only detectable in tissue samples but in body fluids as well. Consequently, a systemic diagnostic approach by determination of distinct expression pattern in e.g., peripheral blood samples will support the characterization of distinct cardiomyopathies by means of non-invasive methods.
维普期刊数据库