CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity

作     者：Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock 

作者机构：Institute of ImmunologyInterdisciplinary Center for Clinical Research(IZKF)University of MuensterMuensterGermany IZKF Research Group 5Interdisciplinary Center for Clinical Research(IZKF)University of MuensterMuensterGermany Department of PediatricsRWTH Aachen UniversityAachenGermany Beth Israel Deaconess HospitalHarvard Medical SchoolBostonMAUSA Department of Medicine IIRWTH Aachen UniversityAachenGermany Institute of AnatomyUniversity of CologneCologneGermany Department of Medicine IIIRWTH Aachen UniversityAachenGermany Department of DermatologyInterdisciplinary Center for Clinical Research(IZKF)University of MuensterMuensterGermany Institute of Experimental Pathology(ZMBE)Interdisciplinary Center for Clinical Research(IZKF)University of MuensterMuensterGermany Interdisciplinary Center for Clinical Research(IZKF)AachenRWTH Aachen UniversityGermany 

出 版 物：《分子细胞生物学报:英文版》 (Journal of Molecular Cell Biology)

年 卷 期：2012年第4卷第2期

页      面：121-123页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：TH17 induce cytokines 

摘      要：Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine *** from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells).