Intramedullary Spinal Cord Glioma Following Microinjection of Glioblastoma Cell Line C6 in Rats
Intramedullary Spinal Cord Glioma Following Microinjection of Glioblastoma Cell Line C6 in Rats作者机构：1st Neurosurgery Clinic in Bakirkoy Mental Diseases Hospital Bakirkoy Istanbul Turkey Department of Histology and Embryology Abant Izzet Baysal University Medical School Bolu Turkey Department of Neurosurgery Abant Izzet Baysal University Medical School Bolu Turkey Department of Pathology Abant Izzet Baysal University Medical School Bolu Turkey
出 版 物：《Open Journal of Modern Neurosurgery》 (现代神经外科学进展（英文）)
年 卷 期：2014年第4卷第1期
页 面：43-46页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Intramedullary Spinal Cord Glioma Animal Model C6 Glioblastoma Cell
摘 要：Background: This paper describes the establishment of a rat intramedullary spinal cord tumor (IMSCT) model and histopathological characterization of the tumor model. Methods: Fourteen male Wistar rats were randomized into two groups. The rats in group 1 (control group, n = 7) received a 5 μl intramedullary injection of serum physiologic (SF). Those in group 2 (experimental group, n= 7) received a 5 μl intramedullary implantation of media containing 5 × 105 C6 glioma cells. The animals were sacrificed for histopathological examination at 21 days. Results: The control group showed normal functional and histopathological findings. The group 2 rats implanted with C6 glioblastoma cells developed hind-limb paraplegia. Pathological sections confirmed intramedullary C6 glioblastoma invading the spinal cord. Conclusions: A rat C6 IMSCT model was successfully established. This model may be useful in increasing understanding of intramedullary spinal cord gliomas in humans.
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