Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas

作     者：Piera Zaccari Vincenzo Cardinale Carola Severi Federica Pedica Guido Carpino Eugenio Gaudio Claudio Doglioni Maria Chiara Petrone Domenico Alvaro Paolo Giorgio Arcidiacono Gabriele Capurso 

作者机构：Department of Internal Medicine and Medical SpecialtiesGastroenterology UnitSapienza University of RomeRome 00161Italy Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of Rome00161 RomeItaly Pathology DepartmentPancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilan 20132Italy Department of MovementHuman and Health SciencesDivision of Health SciencesUniversity of Rome"Foro Italico"Rome 00161Italy Department of AnatomicalHistologicalForensic Medicine and Orthopedics SciencesDivision of Human AnatomySapienza University of RomeRome 00161Italy PancreatoBiliary Endoscopy and EUS DivisionPancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilan 20132Italy Department of Translational and Precision MedicineSapienza University of RomeRome 00161Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第31期

页      面：4343-4359页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Associazione Italiana Ricerca sul Cancro Italy No.AIRC:IG 17177 to Capurso G 

主　　题：Biliary Pancreatic Progenitors Preneoplastic Common Tumor 

摘      要：the bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin.Consequently,preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular,histological and pathophysiological features.Intraepithelial neoplasms are reported in biliary tract,as biliary intraepithelial neoplasm(BilIN),and in pancreas,as pancreatic intraepithelial neoplasm(PanIN).Both can evolve to invasive carcinomas,respectively cholangiocarcinoma(CCA)and pancreatic ductal adenocarcinoma(PDAC).Intraductal papillary neoplasms arise in biliary tract and pancreas.Intraductal papillary neoplasm of the biliary tract(IPNB)share common histologic and phenotypic features such as pancreatobiliary,gastric,intestinal and oncocytic types,and biological behavior with the pancreatic counterpart,the intraductal papillary mucinous neoplasm of the pancreas(IPMN).All these neoplastic lesions exhibit similar immunohistochemical phenotypes,suggesting a common carcinogenic process.Indeed,CCA and PDAC display similar clinic-pathological features as growth pattern,poor response to conventional chemotherapy and radiotherapy and,as a consequence,an unfavorable prognosis.The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells.