Metabolic memory: mechanisms and implications for diabetic vasculopathies

作     者：ZHANG ErLi WU YongJian 

作者机构：State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第8期

页      面：845-851页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(91339103) 

主　　题：diabetic vascular complications metabolic memory oxidative stress inflammation epigenetic modifications 

摘      要：In the past decades,a persistent progression of diabetic vascular complications despite reversal of hyperglycemia has been observed in both experimental and clinical *** durable effect of prior hyperglycemia on the initiation and progression of diabetic vasculopathies was defined asmetabolic memory.Subsequently,enhanced glycation of cellular proteins and lipids,sustained oxidative stress,and prolonged inflammation were demonstrated to mediate this ***,emerging evidence strongly suggests that epigenetic modifications may account for the molecular and phenotypic changes associated with hyperglycemic *** this review,we presented an overview on the discovery of metabolic memory,the recent progress in its molecular mechanisms,and the future implications related to its fundamental research and clinical application.