HMGR, SQS, β-AS, and Cytochrome P450 Monooxygenase Genes in Glycyrrhiza uralensis

作     者：Rui Yang Bo-chuan Yuan Yong-sheng Ma Li-qiang Wang Chun-sheng Liu Ying Liu 

作者机构：School of Chinese Pharmacy Beijing University of Chinese Medicine 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2015年第7卷第4期

页      面：290-295页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Beijing Project for Young Talents(YETP0819) National Science Foundation of China(81503181) 

主　　题：β AS cytochrome P450 monooxygenase functional genes glycyrrhizin HMGR SQS 

摘      要：Glycyrrhiza uralensis is frequently used in traditional Chinese medicine. This plant contains a large amount of effective constituents, including triterpenoids and flavonoids. Among them, glycyrrhizin is believed to be the marker compound to evaluate the quality of G. uralensis based on Chinese Pharmacopoeia. Many studies showed that glycyrrhizin possesses various pharmacological activities, such as antibacterial, antiviral, antitumor, anti-inflammatory, and immune-stimulating activities. In this paper, we summarized the cloning, characterization, expression, and polymorphism analysis of several functional genes involved in glycyrrhizin biosynthesis in G. uralensis.