Neurotoxicity and Biomarkers of Lead Exposure: a Review

作     者：Kang-sheng Liu Jia-hu Hao Yu Zeng Fan-chun Dai Ping-qing Gu 

作者机构：State Key Laboratory of Reproductive Medicine Department of Clinical Laboratory Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of Maternity and Child Health Care School of Public HealthAnhui Medical University Child Health Care Department Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Obstetrical Department Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of Epidemiological and Health Statistics School of Public Health of Nanjing Medical University 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2013年第28卷第3期

页      面：178-188页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

主　　题：lead poisoning biological monitoring neurotoxicity neurodevelopment 

摘      要：Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention *** is one of the neurotoxicants that seems to be involved in the etiology of *** are generally classified into three groups:biomarkers of exposure,effect,and *** main body compartments that store lead are the blood,soft tissues,and bone;the half-life of lead in these tissues is measured in weeks for blood,months for soft tissues,and years for *** the brain,lead-induced damage in the prefrontal cerebral cortex,hippocampus,and cerebellum can lead to a variety of neurological disorders,such as brain damage,mental retardation,behavioral problems,nerve damage,and possibly Alzheimer’s disease,Parkinson’s disease,and *** paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.