Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives

作     者：Li Ma Mei-Sze Chua Ourania Andrisani Samuel So 

作者机构：Asian Liver Center and Department of SurgeryStanford University School of MedicineStanford UniversityStanfordCA 94305United States Department of Basic Medical Science and Center for Cancer ResearchPurdue UniversityWest LafayetteIN 47907United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第2期

页      面：333-345页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK, (R01DK044533) National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK 

主　　题：Hepatocellular carcinoma Epigenetics DNA methylation Histone modification miRNA lncRNA 

摘      要：Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health *** dismal prognosis has prompted recent significant advances in the understanding of its etiology and *** deregulation of epigenetic mechanisms,which maintain heritable gene expression changes and chromatin organization,is implicated in the development of multiple cancers,including *** review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC,with an emphasis on HCC mediated by chronic hepatitis B virus *** review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers,and highlights the future potential of similar therapies in the treatment of HCC.