Idiopathic pulmonary fibrosis will increase the risk of lung cancer

作     者：Li Junyao Yang Ming Li Ping Su Zhenzhong Gao Peng Zhang Jie 

作者机构：Department of Respiratory and Critical Care Medicinethe Second Affiliated Hospital of Jilin University Changchun Jilin 130041China Centre for Asthma and Respiratory Disease School of Biomedical Sciences and Pharmacy Faculty of Health University of Newcastle and Hunter Medical Research Institute Callaghan New South Wales 2230 Australia Department of Pediatrics the second Affiliated Hospital of Jilin University Changchun Jilin 130041China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第17期

页      面：3142-3149页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This article was supported by grants from the National Natural Science Foundation of China (No.81241069 and No.30971315) Programs Foundation of Ministry of Education of China (No.20120061110073) and International Cooperation Program of Jilin Province (No.20140414066GH) 

主　　题：idiopathic pulmonary fibrosis lung cancer prevalence risk factors 

摘      要：Objective To review the studies investigating the increased risk of lung cancer in patients with idiopathic pulmonary fibrosis （IPF）.Data sources Data cited in this review were obtained mainly from PubMed and Medline from 1999 to 2013 and highly regarded older publications were also *** selection We identified,retrieved and reviewed the information on the frequency,risk factors,anatomical features,histological types,clinical manifestations,computed tomography findings and underlying mechanisms of lung cancer in IPF *** The prevalence rates of lung cancer in patients with IPF （4.8％ to 48％） are much higher than patients without IPF （2.0％ to 6.4％）.The risk factors for lung cancer in IPF include smoking,male gender,and *** cancers often occur in the peripheral lung zones where fibrotic changes are *** and squamous cell carcinoma are the most common types of lung cancer in patients with *** features of these patients include peripherally located,ill-defined mass mimicking air-space *** underlying mechanisms of the development of lung cancer in patients with IPF have not been fully understood,but may include the inflammatory response,epithelial injury and/or abnormalities,aberrant fibroblast proliferation,epigenetic and genetic changes,reduced cell-to-cell communication,and activation of specific signaling *** These findings suggest that IPF is associated with increased lung cancer *** is necessary to raise the awareness of lung cancer risk in IPF patients among physicians and patients.