A meta-analysis based on case-control studies shows the similar prognosis between male and female patients with breast cancer

作     者：Feifei Zhou Rong Huang Jun Jiang Fang Wang Wenzhuo He Guifang Guo Liangping Xia 

作者机构：Tumor Center The Foshan First People＇s Hospital Foshan 528000 China State Key Laboratory of Oncology in South China Guangzhou 510060 China VIP Region Sun Yat-sen University Cancer Center Guangzhou 510060 China 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2011年第10卷第6期

页      面：311-316页

学科分类：090603[农学-临床兽医学] 12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 08[工学] 09[农学] 0906[农学-兽医学] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：Supported by a grant from the Major Science and Technology Project of "National Significant New Drug Creation" (No. 2008ZX09312-002) 

主　　题：male breast cancer (MBC) female breast cancer (FBC) meta-analysis prognosis 

摘      要：Objective： Male breast cancer （MBC） is a rare disease, and studies to compare the prognosis between the MBC and female breast cancer （FBC） available now were case-control studies and population-based studies, however, with controversial outcomes. To further investigate whether sex affects the prognosis of breast cancer, we performed a meta-analysis based on all the peered papers. Methods： The PubMed database was screened. Subsequently, the hazard ratios （HRs） for overall survival （OS） and disease special survival （DSS）, were pooled using the Review Manager 5.0 package. Results： This study comprised of 254 MBC and 733 FBC patients enrolled in six case-control studies. There was no statistically significant heterogeneity among the trials for either outcome variable. The pooled HR showed that there was no significant difference in 5-year or 10-year DSS （HR： 1.25, 95% CI： 0.76-2.08; HR： 1.04, 95% CI： 0.68-1.5g） and 5-year or 10-year OS （HR： 0.76, 95% CI： 0.51-1.14; HR： 0.74, 95% CI： 0.54-1.02） between MBCs and FBCs. Conclusion： MBC and FBC with similar prognosis are found in this meta-analysis based on only case-control studies which matched main potential prognostic factors such as age, clinical stage, and time at diagnosis.