Recurrent ischemic stroke as an initial manifestation of an concealed pancreatic adenocarcinoma： Trousseau＇s syndrome

作     者：Semih Giray Feyzi Birol Sarica Zulfikar Arlier Nebil Bal 

作者机构：Department of NeurologyBaskent University Faculty of Medicine Adana 01250 Turkey 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第4期

页      面：637-640页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 12[管理学] 120203[管理学-旅游管理] 1202[管理学-工商管理] 08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

主　　题：disseminated intravascular coagulation ischemic stroke pancreas adenocarcinoma Trousseau's syndrome 

摘      要：In rare instances, stroke may preceed a diagnosis of cancer and be the first clinical evidence of an underlying *** infarction mostly complicates lymphomas, carcinomas, and solid tumors. Malignancy-related thromboembolism can present as acute cerebral infarction, nonbacterial thrombotic endocarditis and migratory thrombophlebitis. It is generally attributed to a cancer-related hypercoagulable period, chronic dissemiated intravascular coagulopathy （DIC）, or tumor embolism. We reported a case of malignancy-releated thromboembolism from an undiagnosed pancreatic adenocarcinoma in a 54-year-old man, who presented with recurrent ischemic stroke due to chronic DIC. He died of the underlying malignancy despite the appropriate institution of anticoagulation *** case emphasizes that cerebral infarction may be the first manifestation of an undiagnosed cancer. If there is laboratory or clinical evidence associated with DIC, patients with a cerebral infarct of an unknown etiology should be investigated for a malignant process. The optimal method of anticoagulation in cancer patients with thromboembolic disease （TED） remains unclear.