Toll-like receptors,a double-edged sword in immunity to malaria

作     者：Chen Jide He Ying Xu Wenyue Huang Fusheng 

作者机构：Department of Pathogenic Biology College of Basic Medical Sciences Third Military Medical University Chongqing 400038 China Department of Clinical Laboratory Chongqing Public Health Hospital Center Chongqing 400036 China 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2009年第24卷第2期

页      面：118-124页

学科分类：100406[医学-军事预防医学] 12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：Toll-like receptors Innate immunity Malaria Plasmodium 

摘      要：Toll-like receptors(TLRs) are a central component of innate immune system and play a major role as the initiator of the innate immune responses to defend against bacteria,viruses,parasite and other *** malaria infection,TLRs signaling pathways are initialed with the recognition of Plasmodium glycosylphosphatidylinositols(GPI) and hemozoin as pathogen-associated molecular patterns(PAMPs).And then,activation of TLRs signaling induces specific biological responses against malaria parasites ***,TLRs are also involved in malaria pathogenesis and enhancement of immune tolerance and evasion for malaria ***,malaria parasites regulate selectively TLRs expression on immune ***,these evidences indicated that TLRs have contrary roles on malaria *** the complicated roles of TLRs on malaria infection will contribute us to design more effective anti-malaria drugs or vaccines.