Influence of cromolyn sodium and compound 48/80 administered prior to and after reperfusion on the third day＇s survival rate in a rat intestinal ischemia model
Influence of cromolyn sodium and compound 48/80 administered prior to and after reperfusion on the third day＇s survival rate in a rat intestinal ischemia model作者机构：Department of Anesthesiology Third Affiliated Hospital Sun Yat-Sen University Guangzhou Guangdong 510630 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2008年第121卷第18期
页 面：1843-1847页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Scientific and Technological Project Foundation of Guangdong Province China [2007B060401070]
主 题：intestinal ischemia reperfusion cromolyn sodium compound 48/80 mast cells survival rate
摘 要：Intestinal ischemia occurs in a wide variety of clinical manifestations. The gut barrier is broken down by bacterial translocation after small intestinal ischemia reperfusion injury （IIRI）, which can result in many clinical consequences, even death. The intestinal mucosal mast cells （IMMCs） serve as a unique cellular source of large amounts of vasoactive mediators, and they can influence local tissue reactions. We and others have previously shown that IIRI could activate IMMCs, make them degranulate and release a mass of inflammatory mediators, which in turn aggravate IIRI.
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