Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke

作     者：Luo, C. X. Jiang, J. Zhou, Q. G. Zhu, X. J. Wang, W. Zhang, Z. J. Han, X. Zhu, D. Y. 

作者机构：Nanjing Med Univ Sch Pharm Dept Pharmacol. Nanjing Peoples R China. Chinese Acad Sci Shanghai Inst Biol Sci Inst Neurosci Shanghai Peoples R China. Nanjing Med Univ Lab Mammalian Genes Nanjing Peoples R China. 

出 版 物：《南京医科大学学报（自然科学版）》 (Journal of Nanjing Medical University(Natural Sciences))

年 卷 期：2007年第27卷第10期

页      面：1155-1155页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：神经发生 齿状回 空间记忆恢复 中风 大脑 

摘      要：Spatial cognitive impairment is common after stroke *** exercise could improve the impaired spatial *** generated neurons in the dentate gyrus are necessary for the acquisition of new hippocampus-dependent ***, it is not well known whether voluntary exercise after stroke promotes neurogenesis in the adult clentate gyrus, thereby promoting spatial memory ***, we examined in mice subjected to focal cerebral ischemia the effect of voluntary or forced exercise on neurogenesis in the ischemic clentate gyrus and spatial *** to voluntary wheel running after stroke enhanced newborn cell survival and up-regulated the phosphorylation of cAMP response element binding protein (CREB) in the clentate gyrus and reversed ischemia-induced spatial memory impairment.