Changes of plasma D(-) -lactate, diamine oxidase and endotoxin in patients with liver cirrhosis

作     者：Peng Ruan, Zuo-Jiong Gong and Quan-Rong Zhang Wuhan, China Department of Infectious Diseases, Renmin Hospital Wuhan University Medical College, Wuhan 430060 , China 

作者机构：Department of Infectious Diseases Renmin Hospital Wuhan University Jiefang Road Wuhan 430060 China. 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2004年第3卷第1期

页      面：58-61页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：liver cirrhosis D(-)-lactate diamine oxidase endotoxin intestinal permeability gut failure 

摘      要：BACKGROUND: Plasma D(-)-lactate and diamine oxidase (DAO) can reflect patients intestinal mucosal condition. We evaluated the changes of plasma D (-)-lactate, DAO and endotoxin activities and their significance in patients with liver cirrhosis. METHODS: Fifty liver cirrhosis patients were enrolled into experimental group and 30 healthy people into control group. The plasma levels of D(-)-lactate, DAO and endo- toxin were detected spectrophotographically. RESULTS: The level of D(-)-lactate was significantly high- er in the experimental group than that in the control group (P0.01). Significant differences of D (-)-lactate levels were observed in Child-Pugh subgroups of the experimen- tal group (P 0. 01). The level of DAO was significantly higher in the experimental group than that in the control group (P 0.01), but the level of DAO in Child-Pugh sub- group C was significantly lower than that in Child-Pugh subgroup B (P0.01). The level of endotoxin was signifi- cantly increased in the experimental group except Child Pugh subgroup A (P0.01). The plasma levels of D(-) lactate, DAO and endotoxin were positively correlated with each other (P0.01). CONCLUSIONS: The data suggest that both plasma D(-) lactate and DAO activity are sensitive markers for early diagnosis of gut failure and endotoxemia in patients with liver cirrhosis. The impairment of intestinal barrier func- tion may be one of the critical reasons for deterioration of liver cirrhosis.