Study on the synthesis and antimicrobial activity of novel cationic porphyrins

作     者：Ke Gui Yu Dong Hong Li Cheng He Zhou Jun Lin Diao 

作者机构：State Key laboratory of Trauma Burn and Combined Injury The 2nd Department of Research Institute of Surgery Dapin Hospital Third Military Medical University Chongqing 400042 China School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第4期

页      面：411-414页

核心收录：

学科分类：090603[农学-临床兽医学] 1007[医学-药学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 0703[理学-化学] 10[医学] 

基　　金：the School of Pharmacy of Southwest University for their partial support to this work 

主　　题：Cationic porphyrin Synthesis Antimicrobial activity Gram-positive bacteria Gram-negative bacteria Fungus 

摘      要：A novel series of quaternary ammonium cationic derivatives based on tetrapyridyl-porphyrin was synthesized. All the compounds were evaluated for their in vitro antibacterial activities against S. aureus, E. coli and P. aeruginosa, and antifungal activities against C. albicans, where microorganisms were exposed and unexposed to the irradiation. The results revealed that some of these compounds, especially, 3a and 4a displayed satisfactory antibacterial activity against Gram-positive bacteria S. aureus and moderate antifungal activity against C. albicans. Unfortunately, Gram-negative bacteria P aeruginasa was resistant to all compounds. The antimicrobial activity was found to be sensitive to the functional groups attached on the aromatic ring and the complex metal in the porphyrin ring, and decreased with the increase of electron-withdrawing capability of the functional groups. These preliminary results suggested that the remarkable antibacterial efficiency against S. aureus makes these substances promising antimicrobial agents.