CELL AND MOLECULAR BIOMECHANICS: PERSPECTIVES AND CHALLENGES

作     者：Baohua Ji Gang Bao 

作者机构：Department of Applied Mechanics Beijing Institute of Technology Beijing 100081 China Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA 30332 USA 

出 版 物：《Acta Mechanica Solida Sinica》 (固体力学学报（英文版）)

年 卷 期：2011年第24卷第1期

页      面：27-51页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 090603[农学-临床兽医学] 07[理学] 09[农学] 0906[农学-兽医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0701[理学-数学] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：supported by the National Heart,Lung,and Blood Institute,National Institutes of Health,as a Program of Excellence in Nanotechnology Award,N01 HV-08234,to Gang Bao the support from the National Natural Science Foundation of China through Grant Nos.10872115,11025208 and 10732050 

主　　题：molecular biomechanics cell mechanics protein mechanics cell adhesion cell migration mechanotransduction 

摘      要：As an intriguing interdisciplinary research field, cell and molecular biomechanics is at the cutting edge of mechanics in general and biomechanics in particular. It has the potential to provide a quantitative understanding of how forces and deformation at tissue, cellular and molecular levels affect human health and disease. In this article, we review the recent advances in cell and molecular biomechanics, examine the available computational and experimental tools, and discuss important issues including protein deformation in mechanotransduction, cell deformation and constitutive behavior, cell adhesion and migration, and the associated models and theories. The opportunities and challenges in cell and molecular biomechanics are also discussed. We hope to provide readers a clear picture of the current status of this field, and to stimulate a broader interest in the applied mechanics community.