The Oligopeptide Transporters： A Small Gene Family with a Diverse Group of Substrates and Functions？

作     者：Mark Lubkowit 

作者机构：Department of Biology Saint Michael's College 1 Winooski Park Colchester VT 05439 USA 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2011年第4卷第3期

页      面：407-415页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 10[医学] 

基　　金：国家自然科学基金 

主　　题：Molecular transport nutrient and metal transport transporters Oligopeptide Transporters. 

摘      要：Genes in the Oligopeptide Transport family encode integral membrane proteins that are believed to trans- locate their substrates from either the extracellular environment or an organelle into the cytosol. Phylogenetic analyses of plant transporters have revealed two distant clades. the Yellow Stripe-Like （YSL） proteins and the so-called Oligopeptide Transporters （OPTs）, for which the family was named. Three categories of substrates have been identified for this family： small peptides, secondary amino acids bound to metals, and glutathione. Notably, the YSL transporters are involved in metal homeostasis through the translocation of metal-chelates, indicating a level of conservation both in biological func- tion as well as substrates. In contrast, the functions of OPT proteins seem to be less defined and, in this review, I will examine the supporting and contradictory evidence for the proposed roles of OPTs in such diverse functions as long-dis- tance sulfur distribution, nitrogen mobilization, metal homeostasis, and heavy metal sequestration through the transport of glutathione, metal-chelates, and peptides.