Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma

作     者：Shahriar Behboudi Stephen P Pereira 

作者机构：UCL Institute of HepatologyUniversity College LondonRoyal Free Hospitals 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2010年第2卷第7期

页      面：256-260页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by a project grant from Association for International Cancer Research 

主　　题：Hepatocellular carcinoma Alpha-fetoprotein Cell-mediated immunity Immunotherapy 

摘      要：The presence of CD8 T cell responses to tumor associated antigens have been reported in patients with different malignancies. However, there is very little inf ormation on a comparable CD8 and CD4 T cell response to a tumor antigen in liver cancer patients. Here, we re-examine the kinetic and the pattern of T helper 1 and cytotoxic T lymphocyte responses to alpha-fetoprotein (AFP),a tumor rejection antigen in hepatocellular carcinoma (HCC). Then, we discuss the possibility of using AFP-based immunotherapy in combination with necrotizing treatments in HCC patients.