Comparison of solid dispersion and nanosuspension for improvement of drug absorption
Comparison of solid dispersion and nanosuspension for improvement of drug absorption作者机构：School of Pharmacy Shenyang Pharmaceutical University
出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)
年 卷 期：2016年第11卷第1期
页 面：10-11页
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床]
基 金：National Natural Science Foundation of China NSFC (81173008)
主 题：Nanosuspension Solid dispersion In vitro In vivo
摘 要：Currently, drug discovery technology is heavily dependent oncombinatorial chemistry and high throughput screening, resultingin more and more poorly water-soluble drugs, eitherclass II (low solubility and high permeability) or IV (low solubilityand low permeability) in the standard biopharmaceuticalclassification system. Owing to the importance of solubility/dissolution for oral absorption, formulation scientists face agreat challenge.Thus, strategies have been proposed to improvethe solubility and dissolution rate. Among these approaches,solid dispersion [1] and nanosuspension [2] are the most usuallyused. However, which one is better for improving the in vitrodissolution and in vivo bioavailability?
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