Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination

作     者：Zeyu Xu Xingxing Jiang Shuping Liu Minghui Yang Zeyu Xu;Xingxing Jiang;Shuping Liu;Minghui Yang

作者机构：Key Laboratory of Hunan Province for Water Environment and Agriculture Product SafetyCollege of Chemistry and Chemical EngineeringCentral South University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第1期

页      面：185-188页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 080202[工学-机械电子工程] 08[工学] 0817[工学-化学工程与技术] 1010[医学-医学技术（可授医学、理学学位）] 070302[理学-分析化学] 0703[理学-化学] 0802[工学-机械工程] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China (No.21575165) 

主　　题：Electrochemical sensor Doxcycline hyclate Molecularly imprinted polymers Multi-walled carbon nanotubes Electro-polymerization 

摘      要：An electrochemical sensor for doxycycline hyclate(DC)detection with high sensitivity and good selectivity is *** sensor was fabricated by electro-polymerization of molecularly imprinted polymers(MIPs)in the presence of DC onto multi-walled carbon nanotubes modified glassy carbon electrode(MWCNTs/GCE).The MWCNTs can significantly increase the current response of the sensor,leading to enhanced *** MIPs provide selective recognition sites for DC *** experimental parameters,such as the polymer monomer concentration,supporting electrolyte pH,the time for electro-polymerization and the incubation time of the sensor with DC were *** optimized experimental conditions,the sensor displayed a linear range of 0.05μmol/L-0.5μmol/L towards DC detection,with the detection limit of 1.3×10^-2μmol/*** sensor was successfully applied for recovery test of DC in human serum samples.