A novel and efficient synthesis of pyrazolo[3,4-d]pyrimidine derivatives and the study of their anti-bacterial activity

作     者：Shahnaz Rostamizadeh Masoomeh Nojavan Reza Aryan Hamid Sadeghian Mahdieh Davoodnejad 

作者机构：Department of ChemistryFaculty of ScienceK.N.Toosi University of TechnologyP.O.Box 15875-4416TehranIran Department of ChemistryFaculty of ScienceUniversity of ZabolZabolIran Resistance Research CenterBuali Research InstituteMashhad University of Medical SciencesMashhad 91967-73117Iran Department of Laboratory SciencesSchool of Paramedical SciencesMashhad University of Medical SciencesMashhad 91857-63788Iran 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第7期

页      面：629-632页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：Pyrrazolo[3 4-d]pyrimidine derivatives Pyrimidine-5-carbonitrile derivatives Antibacterial activity Staphylococcus aureus Enterococcus raffinosus 

摘      要：In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot, three-component reaction of an aldehyde, malononitrile and benzamidine hydrochloride, in the presence of magnetic nano Fe304 particles as a catalyst under solvent-free conditions. 3-Amino-6-aryl- 2-phenylpyrazolo[3,4-d]pyrimidine derivatives were prepared through an efficient and environmentally friendly reaction between 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives and hydra- zine hvdrate and their antibacterial activity has been evaluated