Ir-catalyzed regiospecific mono-sulfamidation of arylquinazolinones

作     者：Yadong Feng Zhenyue Zhang Qi Fu Qiuhong Yao Huabin Huang Jinhai Shen Xiuling Cui Yadong Feng;Zhenyue Zhang;Qi Fu;Qiuhong Yao;Huabin Huang;Jinhai Shen;Xiuling Cui

作者机构：College of Environment and Public HealthXiamen Huaxia UniversityXiamen 361024China Engineering Research Center of Molecular Medicine of Ministry of EducationKey Laboratory of Fujian Molecular MedicineKey Laboratory of Xiamen Marine and Gene DrugsSchool of Biomedical SciencesHuaqiao UniversityXiamen 361021China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第1期

页      面：58-60页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (No.21572072) Xiamen Southern Oceanographic Center (No.15PYY052SF01) 111 Project (No.BC2018061) the Postgraduates Innovative Fund in Scientific Research of Huaqiao University the financial support of Scientific Research Foundation of Xiamen Huaxia University (No. HX201807) Outstanding Youth Scientific Research Cultivation Plan in Fujian Province University (2018) 

主　　题：Ir-catalyzed C-H activation Mono-sulfamidation Selectivity Arylquinazolinones 

摘      要：An Ir-catalyzed selective mono-sulfamidation of 2-arylquinazolinones has been achieved with a low catalyst loading under mild conditions.A series of regioselective mono-sulfamided 2-arylquinazolinones were obtained in up to 90%yields.Compared with our previous work of constructing di-sulfamidated 2-arylquinazolinones,the mono-sulfamided products could be obtained selectively by changing the ratio of substrates,the loading of catalyst,acid additive,and reaction time.