Preventive and Therapeutic Role of Vitamin E in Chronic Plumbism

作     者：MAMTADHAWAN S.J.S.FLORA S.K.TANDON 

作者机构：Industrial Toxicology Research CentreP.O.Box 80Lucknow-226001India 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1989年第2卷第4期

页      面：335-340页

核心收录：

学科分类：10[医学] 

主　　题：Preventive and Therapeutic Role of Vitamin E in Chronic Plumbism ALAD 

摘      要：The ability of vitamin E to prevent or treat experimental lead intoxication was investigated in *** ingestion(10 mg/kg,lead as lead acetate,orally fbr 6 weeks)significantly inhibited the activity of blood δ-aminolevulinic acid dehydratase(ALAD),reduced the brain dopamine (DA)contents,enhanced the blood zinc protoporphyrin,and enhanced the urinary excretion of δ-aminolevulinic acid(ALA).Lead exposure also elevated brain norepinephrine,homovanillic acid,and 5-hydroxyindole acetic acid(5-HIAA)levels and concentration of lead in blood and *** supplementation of vitamin E along with lead significantly reduced the inhibition of blood ALAD activity,brain DA and 5-HIAA levels,and elevation of urinary ALA *** and liver lead concentrations were also significantly reduced by simultaneous supplementation with vitamin *** exposure treatment with vitamin E was ineffective in reducing the lead-induced effects,except that the inhibition of blood ALAD activity was slightly *** present results suggest that vitamin E given simultaneously with lead is effective in reducing the severity of lead intoxication.1989 Academic ***.