Stability and Determination of Metamizole Sodium by Capillary Electrophoresis Analysis Combined with Infra-red Spectroscopy

作     者：XIANG Qian NIU Gang WU Xian-hua CHEN Gang 

作者机构：Department of Applied Chemistry Changchun Institute of Technology Changchun 130022 P. R. China Key Laboratory of Automobile Materials of Ministry of Education College of Materials Science and Engineering Jilin University Changchun 130012 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第6期

页      面：654-658页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：Supported by the National Basic Research Program of China(No.2006CB605305) 

主　　题：Capillary electmphoresis Metamizole sodium Stability 

摘      要：Metamizole sodium was chosen as a representative of unstable analytes for investigation by discussing the effects of oxygen and solvent on its degradation reaction using the capillary electmphoresis technique. A possible degradation mechanism was deduced from the observed behavior and was confirmed by infra-red spectroscopic study. The degradation reaction could be inhibited obviously by methanol instead of water as the solvent of analyte. Under the optimized conditions： separation voltage of 20 kV, and 5 mmol/L disodium hydrogen phosphate and 5 mmol/L borax with 10% methanol（pH 9. 12） as the running buffer, the standard curve of metamizole sodium was linear in a range of 3.77- 74. 07 mg/L. A satisfactory result was achieved when the technique was used to detect metamizole sodium in tablet.